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Packaging, not yield, may be problem for nasal-spray H1N1 vaccine

first_imgJul 30, 2009 (CIDRAP News) – While most vaccine manufacturers have reaped below-average crops of H1N1 influenza vaccine virus from the eggs in which they’re grown, MedImmune Inc. has a different problem: high virus yields, but a potential shortage of the devices used to spray the vaccine into the nose.The company has produced more than 20 million bulk doses of the vaccine, well above the 12.8 million ordered so far by the US government, and has the capacity to make 205 million bulk doses, said Ben Machielse, executive vice president of operations, in an interview this week.But he said the company has the capability to put only 41 million doses in sprayers, so it is looking into the possibility of using droppers instead—an option that would require additional regulatory review but may permit making more vaccine available sooner. The Maryland-based company, part of AstraZeneca, makes the seasonal vaccine FluMist, which uses a live but weakened virus.The other manufacturers that have H1N1 vaccine orders from the Department of Health and Human Services (HHS)—Sanofi Pasteur, Novartis, GlaxoSmithKline (GSK), and CSL Biotherapies—have reported that their virus yields so far have been half or less of what they usually get when growing seasonal flu vaccines. (Yesterday an HHS official said yields have improved somewhat, but gave no details.)What the low yields mean for production expectations has been unclear. Three of the manufacturers (Sanofi, Novartis, and GSK), when contacted recently by CIDRAP News, declined to say how many doses they expect to make or how many have been ordered by HHS. A Bloomberg News report yesterday, citing Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, said Novartis is responsible for 45% percent of the supply, while Sanofi will provide 26% and CSL will make 19%.Meanwhile, MedImmune is getting yields as good as or better than it reaps with seasonal vaccine, according to Machielse. “Given the fact that you need a very, very small dose of FluMist, we get a yield of about 80 doses per egg for this strain, and normally the seasonal strain has a yield of 60 to 100 doses per egg,” he said.MedImmune’s better yields may have to do with the fact that the company is using a different seed strain of H1N1, according to Machielse. The injectable-vaccine makers reportedly have been working with a strain developed at New York Medical College. He said MedImmune developed its own strain, combining genes from a wild-type H1N1 virus with the “backbone” genes of the virus used in FluMist.Machielse said HHS officials have expressed interest in ordering additional MedImmune doses beyond the initial 12.8 million but haven’t done so yet. In anticipation of a possible need to supply more doses than it has sprayers for, the company is looking into the dropper option.”The initial clinical development of FluMist was based on dropper administration, so we have a lot of clinical data on dropper administration,” he said. “We’ve contacted BARDA [HHS’s Biological Advanced Research and Development Agency], FDA [the Food and Drug Administration], and the National Vaccine Program Office, and they’re working with us to define a regulatory pathway to get a dropper device approved as soon as possible. We have a rough outline of what needs to be done, and we’re now in discussion with FDA to fine-tune it.”He said the company has told federal officials it could potentially have multidose droppers of its vaccine ready starting in early October. “We are currently working through all the details with suppliers, FDA, and BARDA to see what needs to be done to get to that point, but there are no guarantees because there are many parties involved,” he added.William Schaffner, MD, an immunization expert and chair of the Department of Preventive Medicine at Vanderbilt University in Nashville, said increased availability of MedImmune’s vaccine could help in the effort to immunize children against the new virus. Yesterday the CDC’s immunization advisory committee recommended vaccination for young people from 6 months through 24 years old, along with several other groups.”As a company they’ve really focused on children, so there’s a real potential this could be used widely not only in pediatricians’ offices, but if there are a number of school-based flu immunization programs, FluMist is vastly better than injectable vaccine in a school-based program,” Schaffner said.He said the vaccine, being needle-free, is much easier to administer in large numbers than injectable vaccines.The seasonal version of FluMist is considerably more expensive than injectable flu vaccines. But Schaffner noted that the H1N1 vaccines are being purchased by the federal government, so the cost for recipients or their insurers will mainly be the administrative expense.The administrative costs may be a barrier to school-based immunization programs, which are typically run by local health departments and take “a fair amount of preparation,” Schaffner added.As for possible adult use of MedImmune’s H1N1 vaccine, Schaffner noted that seasonal FluMist has not been used very widely in adults. It is approved for healthy people from ages 2 through 49.”People who have underlying illnesses can’t take FluMist,” Schaffner said. That would appear to rule out one of the groups the CDC committee targeted for H1N1 vaccination: those between 25 and 64 who have chronic medical conditions.last_img read more

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Another record car count set as Taylor builds on Dakota Tour success at Estevan

first_imgESTEVAN, Sask. (July 7) – Despite leading all 30 laps, Jeff Taylor got to enjoy Monday’s Kupper Chevrolet Dakota Classic Tour main event at Estevan Motor Speedway from a couple perspec­tives.Taylor won his second IMCA Xtreme Motor Sports Modified tour event in as many nights while Steven Pfeifer was second and Shawn Anderson fourth in Taylor Chassis rides. “I’d have been happy with either one of them passing me and winning,” Taylor said. “I’d have been tickled to death.” The win was worth $2,000 and came in a contest slowed by caution just once, on lap 12. Curt Lund was third and Shawn Anderson fifth. Seventy-six Modifieds from 14 states and Canada ran at Estevan. That’s the most ever entries for the division north of the border as the series set new car count records in the first two events of 2014. “I never thought about winning the first two races of this series. It’s the first time I’ve ever started a series like this,” said Taylor, who’d topped the Sunday show at Nodak Speedway. “There is some luck involved but we’ve got a good car.” Dalton Flory topped the $800 to win tour feature for IMCA Sunoco Stock Cars, taking the check­ers ahead of defending champion and first-night winner Elijah Zevenbergen. “It’s awesome to get a win on this tour because you’ve got all these heavy hitters here,” said Flory, who led every time around in a 25-lapper than went green to checkers. “I could run with them last year so it was good to be able to show what I can do in a race car.”Flory encountered his first lapped cars just 10 circuits in and caught up with slower cars again with five to go. Zevenbergen peeked inside a couple times but couldn’t catch Flory. He’d won four straight tour starts dating back to last July 9. Brendon LaBatte, Kody Scholpp and Jake Nelson ended third through fifth, respectively. Primary sponsors for Flory’s ride are his parents Joe and Misti. A new series record 36 Stock Cars saw action Monday.The third of six series installments takes both divisions to Williston Basin Speedway for a Tues­day, July 8 program. Pit gates open at 2 p.m., the grandstand opens at 5 p.m., hot laps are at 6 p.m. and racing starts at 7 p.m. Feature Results Modifieds – 1. Jeff Taylor, Cave City, Ark.; 2. Steven Pfeifer, Minot, N.D.; 3. Curt Lund, Redwood Falls, Minn.; 4. Shawn Anderson, Minot, N.D.; 5. Scott Drake, Joplin, Mo.; 6. David Murray Jr., Oberlin, Kan.; 7. Jett Big Eagle, Manor; 8. Jordan Grabouski, Beatrice, Neb.; 9. Mike Jergens, Plover, Iowa; 10. Brian Mullen, Seymour, Wis.; 11. Adam Larson, Ankeny, Iowa; 12. Rusty Koll­man, Carrington, N.D.; 13. Tim Ward, Gilbert, Ariz.; 14. Mike Hansen, Dickinson, N.D.; 15. Shawn Strand, Mandan, N.D.; 16. Eric Burwick, Dickinson, N.D.; 17. Spencer Wilson, Minot, N.D.; 18. Jeremy Keller, Mandan, N.D.; 19. Jordan Huettl, Minot, N.D.; 20. John Hansen, Brush, Colo.; 21. Tanner Matthewson, Redvers; 22. Lance Mari, Imperial, Calif.; 23. Ed Turnbull, Estevan; 24. John Flory, Williston, N.D.; 25. Tracy Domagala, Bismarck, N.D.; 26. Eric Sinness, Williston, N.D. Heat winners were Murray, Anderson, Turnbull, Larson, Lund, Pfeifer, Taylor and Drake.1st “B” feature (top four) – 1. Mullen; 2. Flory; 3. Huettl; 4. Domagala. 2nd “B” feature – 1. Big Eagle; 2. Grabouski; 3. Keller; 4. Ward. 3rd “B” feature – 1. Mari; 2. Kollman; 3. Matthewson; 4. Sinness. 4th “B” feature – 1. Burwick; 2. Jergens; 3. Mike Hansen; 4. John Hansen. Stock Cars – 1. Dalton Flory, Williston, N.D.; 2. Elijah Zevenbergen, Ocheyedan, Iowa; 3. Bren­don LaBatte, Radville; 4. Kody Scholpp, Estevan; 5. Jake Nelson, Williston, N.D.; 6. Jordan Dur­ward, Trenton, N.D.; 7. Dave Swallers, Williston, N.D.; 8. Greg Wichman, Bonduel, Wis.; 9. Na­than Burke, Minot, N.D.; 10. Gregg Mann, Estevan; 11. Jeremy Swanson, Clarinda, Iowa; 12. Aus­tin Daae, Estevan; 13. Jake Lunderby, Sidney, Mont.; 14. Perry Misner, Garden City, Kan.; 15. Terry Davidson, Rosetown; 16. Matt Speckman, Sleepy Eye, Minn.; 17. Rocky Alexander, Estevan; 18. Stefan Klym, Weyburn; 19. Sterling LaBatte, Weyburn; 20. Chris Ellis, Minot, N.D.; 21. Beau Deschamp, Bottineau, N.D.; 22. Cody Nelson, Kenmare, N.D.; 23. Justin Striefel, Minot, N.D.; 24. Scott Yale, Minot, N.D.1st heat (top three) – 1. Scholpp; 2. Jake Nelson; 3. Mann. 2nd heat – 1. Zevenbergen; 2. Bren­dan LaBatte; 3. Burke. 3rd heat – 1. Flory; 2. Daae; 3. Swallers. 4th heat – 1. Wichman; 2. Klym; 3. Yale.1st “B” feature (top six) – 1. Durward; 2. Misner; 3. Swanson; 4. Davidson; 5. Cody Nelson; 6. Alexander. 2nd “B” feature – 1. Speckman; 2. Ellis; 3. Striefel; 4. Lunderby; 5. Sterling LaBatte; 6. Deschamp.30last_img read more

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‘Bizzy’ Boyce laid to rest
first_img… deserves a national award – LumumbaTHE `Angelo Dundee’ of Guyana’s boxing, Maurice `Bizzy’ Boyce, was laid to rest yesterday, at the Le Repentir Cemetery after serving Guyana’s boxing fraternity for more than 48 years.Boyce, who died two Saturdays ago, four days after celebrating his 73rd birth anniversary, was given a hero’s send-off at the Cliff Anderson Sports Hall before his body was taken to its final resting place.Former Presidential Adviser on Empowerment Odinga Lumumba (extreme right) offers his tribute to Maurice `Bizzy’ Boyce at the Cliff Anderson Sports Hall yesterday (Samuel Maughn photo).Former Presidential Adviser on Empowerment Odinga Lumumba (extreme right) offers his tribute to Maurice `Bizzy’ Boyce at the Cliff Anderson Sports Hall yesterday (Samuel Maughn photo).The news of his death came as a shock as it was only weeks ago that Boyce was very actively involved in a card organised by the Guyana Boxing Board of Control (GBBC) at the Giftland Mall, East Coast Demerara.According to reports, even though Boyce was not feeling well on the night of the card, he found the energy to ensure he was part of the card.It was during the night of the very card that Boyce’s longtime friend and Mayor of Georgetown, Patricia Chase-Green, asked him when he will quit the sport.Delivering a tribute to Boyce during the funeral ceremony at the Cliff Anderson Sports Hall yesterday, Mayor Chase-Green acknowledged that she knew Boyce for more than 48 years and it was through her husband, Terrence `Dick Tiger’ Green that she met Boyce and they have shared a close, friendly relationship since then.“At the last boxing card at Giftland, I asked Bizzy when he would ever give up the sport and his reply to me was … I’ll never give up until I breathe my last breath,” Mayor Chase-Green recalled.Georgetown’s Mayor Patricia Chase-Green (4th left) pays her respects to the late Maurice `Bizzy’ Boyce at the Cliff Anderson Sports Hall yesterday (Samuel Maughn Photo).Georgetown’s Mayor Patricia Chase-Green (4th left) pays her respects to the late Maurice `Bizzy’ Boyce at the Cliff Anderson Sports Hall yesterday (Samuel Maughn Photo).She said that Boyce, whom she met for the first time at the Albouystown YMCA, has lived his life how he wanted to and questioned: “How do you tell a man who has lived his life for his country and for the youths of the country to give up. I wish him farewell and may his soul rest in peace.” Mayor Green concluded.Former Presidential Adviser on Empowerment, Odinga Lumumba, feels that the late boxing tactician deserves a national awardLumumba, a former boxing manager and promoter, in his tribute remembered the many times the two of them travelled all over the world with local boxers seeking to mark their names on the international scene.Lumumba remembered seeing Boyce at 04:00hrs to 05:00hrs taking his charges through their paces while doing road work. “This was a man that was dedicated to the sport. Bizzy was sincere and every great boxer that Guyana produced, Bizzy was in some way or the other responsible for that boxer’s success,” Lumumba stated, adding “This is indeed a great loss to Guyana and Bizzy deserves a national award.”Also offering a tribute was GBBC’s treasurer Andrew Thorne who reminded that Boyce started his career as a corner man in 1968, “fetching buckets of water and then he became one of Guyana’s better coaches.According to Thorne, the highpoint of Boyce’s career was when he took Anthony `The Pearl’ Andrews and Wayne ‘Big Truck’ Braithwaite to fight for world titles as well as Michael Benjamin for the Continental of Americas welterweight title.Thorne said Boyce also plied his trade at the world-famous Gleason Gym in New York. “The boxing fraternity will surely miss him. While we’re sad that he is no more, he has left an indelible mark on the sport.”Boyce’s wife Desiree explained that her husband was ill for a while and family members took him to the hospital for treatment but he was not admitted. However, his condition worsened and he was taken back to the hospital and this time was admitted but died the following morning.On learning of Boyce’s death, his close friend and former boxing promoter, Keith Bazilio expressed shock at the news stating that Guyana has suffered a great loss with Boyce’s passing.“Bizzy was not just a coach, he was always looking to see how best he can improve conditions for local boxers. He was always around to give advice to boxers and promoters and even those persons who are charged with the administration of the sport locally.”Among the many boxers Boyce assisted in reaching world-class recognition are: Michael Benjamin for his first defence of the Continental of Americas title against Steve Lorrimer, Michael Reid, Kenny Bristol, Brian Muller, Albert Browne, Andrew `The Pearl’ Andrews for his world title fight against Jorge Castro, in the USA, and Joseph Murray for his FECABOX title fight.Boyce leaves to mourn his wife Desiree, two sons – Jason and Rondell – many grandchildren and close friends.Chronicle Sport extends its heartfelt sympathy to Mrs Boyce and her family during this period of mourning.last_img
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Wake Forest faces Pitt in ACC tourney

first_imgSAVVY SENIORS: Wake Forest’s Brandon Childress, Olivier Sarr and Andrien White have combined to account for 51 percent of the team’s scoring this season, including 50 percent of all Demon Deacons points over the last five games.KEY CONTRIBUTOR: Childress has accounted for 44 percent of all Wake Forest field goals over the last three games. The senior guard has 19 field goals and 17 assists in those games.PASSING FOR POINTS: The Deacs have recently used assists to create baskets more often than the Panthers. Wake Forest has an assist on 48 of 82 field goals (58.5 percent) across its past three outings while Pittsburgh has assists on 26 of 59 field goals (44.1 percent) during its past three games.DID YOU KNOW: The disruptive Pittsburgh defense has forced opponents to turn the ball over on 23.7 percent of all possessions, the 17th-best rate in the nation. Wake Forest has a forced-turnover percentage of only 15.5 percent through 30 games (ranking the Demon Deacons 344th among Division I teams).___ Associated Press Share This StoryFacebookTwitteremailPrintLinkedinRedditNo. 13 seed Pittsburgh (15-16, 6-14) vs. No. 12 seed Wake Forest (13-17, 6-14)Atlantic Coast Conference Tourney First Round, Greensboro Coliseum, Greensboro, North Carolina; Tuesday, 3:30 p.m. EDTBOTTOM LINE: Pittsburgh is set to match up against Wake Forest in the first round of the ACC tournament. The only meeting between the teams this season came on Jan. 4, when the Demon Deacons shot 46.7 percent from the field while limiting Pittsburgh to just 39 percent en route to a 69-65 victory. Wake Forest faces Pitt in ACC tourneycenter_img March 9, 2020 For more AP college basketball coverage: https://apnews.com/Collegebasketball and http://twitter.com/AP_Top25___This was generated by Automated Insights, http://www.automatedinsights.com/ap, using data from STATS LLC, https://www.stats.comlast_img read more

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‘Wood’ you believe it? Goalpost is man of the match

first_imgShare on: WhatsApp London, United Kingdom | AFP | West Ham fans were so relieved by their team’s 1-0 win over Hull last Saturday that they named a goalpost as man of the match after the woodwork saved the Hammers three times.A Mark Noble penalty gave Slaven Bilic’s side the three points in the Premier League clash at the London Stadium but Hull hit the woodwork on no less than three occasions from Andrew Robertson (twice) and Dieumerci Mbokani.“With 57 per cent of the vote congratulations to The Post on securing today’s Man of the Match award!,” tweeted West Ham after the results of their supporters’ poll.The goalpost beat Cheikhou Kouyate (17 percent), Andy Carroll (14) and Winston Reid (12) in the vote.last_img read more

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